Published papers

Title: Near infrared photo-bacterialflora modulation technology realized controlling periodontitis: modulation of disease-associated dysbiosis in oral microbiota using near infrared photo antibacterial targeting therapy (NIR-PAT2) Date: 2026 Journal: Journal of Translational Medicine Link: s12967-026-08336-2.pdf (igy-research.com)

Title: Near Infrared Photo-Antimicrobial Targeting Therapy for Candida albicans Date: 2020 Journal: Advanced Therapeutics. DOI: 10.1002/adtp.202000221 Link: Adv.-Therap.-2020-2000221-Sato.pdf (igy-research.com)

Title: Synergistic effect of anti-Helicobacter pylori urease immunoglobulin Y from egg yolk of immunized hens and Lactobacillus johnsonii No.1088 to inhibit the growth of Helicobacter pylori in vitro and in vivo. Data: 2019 Journal: Vaccine 37 (2019) 3106-3112 Link: Synergistic effect of anti-Helicobacter pylori urease immunoglobulin Y from egg yolk of immunized hens and Lactobacillus johnsonii No.1088…

Title: Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional nonsurgical therapy in periodontitis patients: A randomized controlled clinical trial. Date: 2018 Journal: Journal of Periodontology, 25 July 2018: Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non‐surgical therapy in periodontitis…

Title: Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review. Date: 2017 Journal: Korean Society for Food Science of Animal Resources, 2017, 37(1); 1-9 Link: JAKO201711656579331.pdf (koreascience.or.kr)

Title: Whole genomic analysis of human G12P[6] and G12P[8] rotavirus strains that have emerged in Myanmar. Date: 2015 Journal: PLoS One, 2015, 10(5): e0124965, DOI:10.1371/ jounal.pone. 0124965; 1-24 Link: Whole Genomic Analysis of Human G12P[6] and G12P[8] Rotavirus Strains that Have Emerged in Myanmar (plos.org)  

Title: Effects of oral moisturizing gel containing egg yolk antibodies against Candida albicans in older people Data: 2014 Journal: Gerodontology, 24 JUL 2014; DOI: 10.1111/ ger. 12139; 1-7 Link: http://onlinelibrary.wiley.com/doi/10.1111/ger.12139/ abstract;jsessionid =C0830B44FEB315FF083F671BDC913762.f02t02

Title: Immuno-intervention with immunoglobulin Y in alimentary tract infections as an alternative or adjunct to antimicrobials or vaccines Date: 2014 Journal: Austin Journal of Clinical Medicine, 2014, 1(3); 1-3 Link: Immuno-Intervention with Immunoglobulin Y in Alimentary Tract Infections as an Alternative or Adjunct to Antimicrobials or Vaccines (austinpublishinggroup.com)    

Title: The IgY antibody against P. gingivalis gingipains inhibits alveolar bone resorption on rat experimental periodontitis Data: 2014 Journal: Kanagawa Shigaku, 2014, 49(1); 16-23: http://www.kdc-dent.js-md.net/Archive/ArticleDetail?full_dir=cn0kanas/2014/004901/003 Download:

Title: Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor Data: 2013 Journal: Nutrition & Metabolism, 2013, 10:70; 1-6 Link: 1743-7075-10-70.pdf (biomedcentral.com)

Title: In vitro cytoprotective effect of infant milk formula fortified with human Rotavirus-specific hyperimmune yolk immunoglobulins (IgY) Data: 2013 Journal: Food Science and Biotechnology, 2013, 22(6); 1699-1705 Link: s10068-013-0269-4.pdf (springer.com)

Title: Oral passive IgY-based immunotherapeutics: A novel solution for prevention and treatment of alimentary tract diseases Data: 2013 Journal: Human Vaccines & Immunotherapeutics, 2013, 9（5）; 1039-1048 Link: hvi-9-1039.pdf (nih.gov)

Title: Recombinant Shiga toxin B subunit can induce neutralizing immunoglobulin Y antibody Data: 2012 Journal: Biological & Pharmaceutical Bulletin 2012, 35 (6); 917-923 Link: Biol. Pharm. Bull. 35(6): 917-923 (2012) (jst.go.jp)

Title: Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportuve therapy for rotavirus-associated diarrhea among pediatric patients Data: 2012 Journal: Vaccine, 2012, 30; 4661-4669 Link: Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients – ScienceDirect

Title: Specific egg yolk immunoglobulin as a new preventive approach for Shiga-toxin mediated diseases Data: 2011 Journal: PLoS One 2011, 6(10): e26526; 1-12 Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026526

Title: Anti-cell-associated glucosyltransferase immunoglobulin Y suppression of salivary mutans streptococci in healthy young adults Data: 2011 Journal: The Journal of the American Dental Association, 2011, 142(8); 943-949 Link: Anti–cell-associated glucosyltransferase immunoglobulin Y suppression of salivary mutans streptococci in healthy young adults – The Journal of the American Dental Association (ada.org)

Title: Passive Oral Immunization by Egg Yolk Immunoglobulin (IgY) to Vibrio cholerae effectively Prevents Cholera Data: 2010 Journal: Acta Medica Okayama, 2010, 64(3); 163-170 Link: fulltext.pdf (okayama-u.ac.jp)

Title: Effect of IgY against Candida albicans and Candida spp. adherence and biofilm formation Data: 2009 Journal: Japanese Journal of Infectious Diseases, 2009, 62(5): 337-342 Link: untitled (niid.go.jp)

Title: In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY) Data: 2008 Journal: Vaccine, 2008, 26(17); 2073-2080 Link: http://www.sciencedirect.com/science/article/pii/S0264410X08002326

Title: Clinical and bacteriological evaluation of anti-gingipain egg yolk antibody  Data: 2007 Journal: Shikahozon. 50(3), 358-364, 2007 Link: ja (jst.go.jp)

Title: Effect of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients Data: 2007 Journal: Journal of Oral Science, 2007, 49(3); 201-206 Link: pdf (jst.go.jp)

Title: Activity of anti-Porphyromonas gingivalis egg yolk antibody against gingipains in vitro Data: 2007 Journal: Oral Microbiology Immunology, 2007, 22; 352-355 Link: Activity of anti‐Porphyromonas gingivalis egg yolk antibody against gingipains in vitro – Yokoyama – 2007 – Oral Microbiology and Immunology – Wiley Online Library

Title: Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils Data: 2005 Journal: HELICOBACTER, 2005, 10(1); 43-52 Link: Effect of Dietary Anti‐Urease Immunoglobulin Y on Helicobacter pylori Infection in Mongolian Gerbils – Nomura – 2005 – Helicobacter – Wiley Online Library  

Title: Suppressive effect of functional drinking yogurt containing specific egg yolk immunoglobulin on Helicobacter pylori in humans Data: 2004 Journal: Journal of Dairy Science, 2004, 87(12); 4073-4079 Link: Suppressive Effect of Functional Drinking Yogurt Containing Specific Egg Yolk Immunoglobulin on Helicobacter pylori in Humans (journalofdairyscience.org)

Title: The Effects of Egg-Derived Antibodies to Glucosyltransferases on Dental Caries in Rats Data: 2004 Journal: Caries Research, 2004(1), 38; 9-14 Link: The Effects of Egg-Derived Antibodies to Glucosyltransferases on Dental Caries in Rats – Abstract – Caries Research 2004, Vol. 38, No. 1 – Karger Publishers

Title: Effect of dietary anti-Helicobacter pylori-urease immunoglobuline Y on Helicobacter pylori infection Data: 2004 Journal: Aliment Pharmacol Ther, 2004, 20(1); 185-192 Link: Effect of dietary anti‐Helicobacter pylori‐urease immunoglobulin Y on Helicobacter pylori infection (wiley.com)  

Title: Enhanced reduction of Helicobacter pylori load in precolonized mice treated with combined famotidine and urease-binding polysaccharides Data: 2000 Journal: Antimicrobial Agent and Chemotherapy, 2000, 44; 2492-2497 Link: Enhanced Reduction of Helicobacter pylori Load in Precolonized Mice Treated with Combined Famotidine and Urease-Binding Polysaccharides (asm.org)

Title: Adherence Protects the Binding Sites of Helicobacter pylori Urease from Acid-Induced Damage Data: 2000 Journal: Microbiology and Immunology, 2000, 44(9); 773-776 Link: Adherence Protects the Binding Sites of Helicobacter pylori Urease from Acid‐Induced Damage (wiley.com)

Title: Acid-dependent adherence of Helicobacter pylori urease to diverse polysaccharides Data: 2000 Journal: GASTROENTEROLOGY, 2000, 119; 358-367 Link: g0080000358p (gastrojournal.org)

Title: Oral passive immunization against experimental salmonellosis in mice using chicken egg yolk antibodies specific for Salmonella enteritidis and S. typhimurium Data: 1998 Journal: Vaccine 1998, 16(4): 388-393 Link: Oral passive immunization against experimental salmonellosis in mice using chicken egg yolk antibodies specific for Salmonella enteritidis and S. typhimurium – ScienceDirect

Title: A euthymic Hairless mouse model of Helicobacter pylori colonization and adherence to gastric epithelial cells In vivo Data: 1998 Journal: Clinical and Diagnostic Laboratory Immunology, 1998, 5(4); 578-582 Link: A Euthymic Hairless Mouse Model of Helicobacter pyloriColonization and Adherence to Gastric Epithelial Cells In Vivo (asm.org)

Title: Affinity purification of Helicobacter pylori urease Data: 1998 Journal: The Journal Biological Chemistry, 1998, 273(29); 18130-18138 Link: Affinity Purification of Helicobacter pyloriUrease (jbc.org)  

Title: Passive Immunity for Protection against Mucosal Infections and Vaccination for Dental Caries Data: 1996 Journal: Mucosal Vaccines, 1996, Academic Press, Inc.; 187-197 Link: http://store.elsevier.com/product.jsp?isbn=9780124105805&pagename=search  Book

Title: Lack of cross-reaction of antibodies against cell-associated glucosyltransferase from Streptococcus mutans with human heart tissue Data: 1995 Journal: Advances in Mucosal Immunology, 1995. Plenum Press, New York; 1161-1165 Download:OC-4 1995 Advance in Mucosal Immunology 1161-1165　DC

Title: Passive immunization against experimental salmonellosis in mice by orally administered hen egg-yolk antibodies specific for 14-kDa fimbriae of Salmonella Enteritidis Data: 1994 Journal: Journal of Medical Microbiology 1994, 41 : 29-35 Link: medmicro-41-1-29.pdf (microbiologyresearch.org)

Title: Oral passive immunization against dental caries in rats by use of hen egg yolk antibodies specific for cell-associated glucosyltransferase of Streptococcus mutans Data: 1991 Journal: Infection and Immunity, 1991, 59(11); 4161-4167 Link: Oral passive immunization against dental caries in rats by use of hen egg yolk antibodies specific for cell-associated glucosyltransferase of Streptococcus mutans…

Title: Antigens of Streptococcus mutans and oral passive immunization against dental caries with egg yolk antibodies to the antigens Data: 1991 Journal: Frontiers of Mucosal Immunology. Volume 1., 577-580, 1991, Tsuchiya et al. eds. (Proceedings of the Sixth International Congress of Mucosal Immunology), Elsevier Science Publishers Download:OC-2 1991 Front of Mucosal Immunology (Vol.1) DC

Title: Prevention of Human Rotavirus Infection with Chicken Egg Yolk Immunoglobulins Containing Rotavirus Antibody in Cat Data: 1990 Journal: Japanese Association for Infectious Diseases, 1990, 64; 118-123 Link: _pdf (jst.go.jp)

Title: Purification and characterization of cell-associated glucosyltransferase synthesizing water-insoluble glucan from serotype c Streptococcus mutans Data: 1989 Journal: Journal of General Microbiology, 1989, 135; 335-344 Link: mic-135-2-335.pdf (microbiologyresearch.org)